| 6 |
Ohio Bruins | 11/6/2021 | 5:00 PM | Indiana Lyons Venue-Bosstick Gym | mw21-22 | 111 | 101 | W |
| 14 |
Missouri Capitals | 11/13/2021 | 5:00 PM | Indiana Lyons Venue-Bosstick Gym | mw21-22 | 137 | 113 | W |
| 20 |
River City Gamblers | 11/20/2021 | 5:00 PM | Indiana Lyons Venue-Bosstick Gym | | 135 | 119 | W |
| 24 |
Midwest Falcons | 11/21/2021 | 4:00 PM | Indiana Lyons Venue-Bosstick Gym | mw21-22 | 128 | 87 | W |
| 31 |
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Music City Jazz (Nashville TN) | 12/4/2021 | 5:00 PM | Indiana Lyons Venue-Bosstick Gym | mw21-22 | 110 | 109 | W |
| 37 |
Clarksville Phoenix | 12/11/2021 | 5:00 PM | Indiana Lyons Venue-Bosstick Gym | mw21-22 | 110 | 106 | W |
| 49 |
River City Gamblers | 12/19/2021 | 3:30 PM | James Eagen Civic Center | mw21-22 | 124 | 126 | L |
| 45 |
Missouri Capitals | 12/18/2021 | 6:00 PM | Missouri Capitals-Moberly Area Community College | mw21-22 | 107 | 109 | L |
| 42 |
Ohio Bruins | 12/12/2021 | 2:00 PM | Northside High School | | 104 | 127 | L |
| 54 |
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Vipers Pro Basketball | 1/8/2022 | 5:00 PM | Indiana Lyons Venue-Bosstick Gym | mw21-22 | 147 | 80 | W |
| 59 |
Ohio Kings | 1/9/2022 | 4:00 PM | Middletown High School | mw21-22 | 107 | 117 | L |
| 60 |
Chicago Rebels | 1/15/2022 | 5:00 PM | Indiana Lyons Venue-Bosstick Gym | mw21-22 | 141 | 101 | W |
| 63 |
St Louis Spirits | 1/16/2022 | 3:00 PM | Indiana Lyons Venue-Bosstick Gym | | 2 | 0 | W |
| 72 |
Ohio Burning River Buckets | 1/23/2022 | 4:00 PM | Indiana Lyons Venue-Bosstick Gym | mw21-22 | 92 | 87 | W |
| 67 |
Midwest Falcons | 1/22/2022 | 5:00 PM | De Kalb rec. Center | | 129 | 109 | W |
| 79 |
Ohio Kings | 2/6/2022 | 4:00 PM | Indiana Lyons Venue-Bosstick Gym | | 104 | 110 | L |
| 81 |
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Beaver County Indians | 2/12/2022 | 5:00 PM | Indiana Lyons Venue-Bosstick Gym | | 157 | 93 | W |
| 89 |
Illinois Bulldogs | 2/19/2022 | 5:00 PM | Indiana Lyons Venue-Bosstick Gym | mw21-22 | 127 | 93 | W |
| 96 |
Clarksville Phoenix | 2/20/2022 | 4:00 PM | Indiana Lyons Venue-Bosstick Gym | mw21-22 | 100 | 113 | L |
| 97 |
Music City Jazz (Nashville TN) | 2/26/2022 | 5:00 PM | Music City Jazz - John Early Middle School | mw21-22 | 111 | 106 | W |
| 100 |
Clarksville Phoenix | 2/27/2022 | 4:00 PM | TBA | | 97 | 107 | L |
| 101 |
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Chicago Knights | 3/5/2022 | 5:00 PM | Bostic Gym | mw21-22 | 101 | 91 | W |
| 107 |
Chicago Rebels | 3/6/2022 | 4:00 PM | Indiana Lyons Venue-Bosstick Gym | mw21-22 | 130 | 79 | W |
| 111 |
Missouri Capitals | 0 | 9:00 PM | James Eagen Civic Center | mw21-22 | 125 | 97 | W |
| 112 |
Clarksville Phoenix | 03/19/22 | 8:00 PM | James Eagen Civic Center | mw21-22 | 98 | 87 | W |
| 115 |
Music City Jazz (Nashville TN) | 2 | 3:00 PM | James Eagen Civic Center | mw21-22 | 90 | 93 | L |
